Compounds and compositions for the treatment of parasitic diseases

作者: Kumar CHATTERJEE , Arnab , Fang LIANG , Nelson MATHISON , Casey Jacob

DOI:

关键词:

摘要: The invention provides a class of compounds, pharmaceutical compositions comprising such compounds and methods using to treat or prevent malaria.

参考文章(208)
David B. Belanger, Patrick J. Curran, Alan Hruza, Johannes Voigt, Zhaoyang Meng, Amit K. Mandal, M. Arshad Siddiqui, Andrea D. Basso, Kimberly Gray, Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. ,vol. 20, pp. 5170- 5174 ,(2010) , 10.1016/J.BMCL.2010.07.008
Thomas Lübbers, Peter Angehrn, Hans Gmünder, Silvia Herzig, Josef Kulhanek, Design, synthesis, and structure-activity relationship studies of ATP analogues as DNA gyrase inhibitors. Bioorganic & Medicinal Chemistry Letters. ,vol. 10, pp. 821- 826 ,(2000) , 10.1016/S0960-894X(00)00109-8
Thomas Novinson, Bharat Bhooshan, Takayuki Okabe, Ganapathi R. Revankar, Roland K. Robins, Keitaro Senga, H. Robert Wilson, Novel heterocyclic nitrofurfural hydrazones. In vivo antitrypanosomal activity Journal of Medicinal Chemistry. ,vol. 19, pp. 512- 516 ,(1976) , 10.1021/JM00226A013
Guillaume Lemercier, Amaury Fernandez-Montalvan, Jeffrey P. Shaw, Dominik Kugelstadt, Joerg Bomke, Mathias Domostoj, Matthias K. Schwarz, Alexander Scheer, Barbara Kappes, Didier Leroy, Identification and characterization of novel small molecules as potent inhibitors of the plasmodial calcium-dependent protein kinase 1. Biochemistry. ,vol. 48, pp. 6379- 6389 ,(2009) , 10.1021/BI9005122
Jiahui Wu, Dengyou Zhang, Lei Chen, Jianneng Li, Jianling Wang, Chengqing Ning, Niefang Yu, Fei Zhao, Dongying Chen, Xiaoyan Chen, Kaixian Chen, Hualiang Jiang, Hong Liu, Dongxiang Liu, Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate Journal of Medicinal Chemistry. ,vol. 56, pp. 761- 780 ,(2013) , 10.1021/JM301032J
Christian D Doerig, Stopping malaria parasites dead in their tracks. Nature Chemical Biology. ,vol. 4, pp. 334- 335 ,(2008) , 10.1038/NCHEMBIO0608-334
Ji-Xia Ren, Lin-Li Li, Ren-Lin Zheng, Huan-Zhang Xie, Zhi-Xing Cao, Shan Feng, You-Li Pan, Xin Chen, Yu-Quan Wei, Sheng-Yong Yang, Discovery of Novel Pim-1 Kinase Inhibitors by a Hierarchical Multistage Virtual Screening Approach Based on SVM Model, Pharmacophore, and Molecular Docking Journal of Chemical Information and Modeling. ,vol. 51, pp. 1364- 1375 ,(2011) , 10.1021/CI100464B
Chafiq Hamdouchi, Concha Sanchez-Martinez, Joseph Gruber, Miriam Del Prado, Javier Lopez, Almudena Rubio, Beverly A Heinz, None, Imidazo[1,2-b]pyridazines, novel nucleus with potent and broad spectrum activity against human picornaviruses: design, synthesis, and biological evaluation. Journal of Medicinal Chemistry. ,vol. 46, pp. 4333- 4341 ,(2003) , 10.1021/JM020583I
Ana B. Caballero, Antonio Rodríguez-Diéguez, Miguel Quirós, Juan M. Salas, Óscar Huertas, Inmaculada Ramírez-Macías, Francisco Olmo, Clotilde Marín, Guillermo Chaves-Lemaur, Ramón Gutierrez-Sánchez, Manuel Sánchez-Moreno, Triazolopyrimidine compounds containing first-row transition metals and their activity against the neglected infectious Chagas disease and leishmaniasis. European Journal of Medicinal Chemistry. ,vol. 85, pp. 526- 534 ,(2014) , 10.1016/J.EJMECH.2014.08.026