Single nucleotide polymorphisms rs911160 in AURKA and rs2289590 in AURKB mitotic checkpoint genes contribute to gastric cancer susceptibility.
作者： Aner Mesic , Ela Markocic , Marija Rogar , Robert Juvan , Petra Hudler
DOI: 10.1002/EM.22129
关键词:
摘要: BACKGROUND Single nucleotide polymorphisms (SNPs) in mitotic checkpoint genes could confer increased susceptibility to gastric cancer (GC). We investigated the association of Aurora kinase A (AURKA), B (AURKB), C (AURKC), Polo-like 1 (PLK1) and Budding uninhibited by benzimidazol 3, yeast (BUB3) gene with GC risk. MATERIALS AND METHODS Genotyping 6 SNPs AURKA (rs911160 rs8173), AURKB (rs2289590), AURKC (rs11084490), PLK1 (rs42873), BUB3 (rs7897156) was performed using TaqMan genotyping assays. RESULTS Our study demonstrated that rs911160 (AURKA) heterozygous genotype associated an risk (OR = 1.50, 95% CI = 1.01-2.22, P = 0.043). Analysis showed significant for intestinal type (OR = 1.80, 95%CI = 1.01-3.21, P = 0.040) significantly higher women than men (OR = 2.65, 95%CI = 1.02-6.87, P = 0.033). SNP rs2289590 might contribute development cancer, particularly (OR = 2.08, CI = 1.05-4.09, P = 0.032). CONCLUSION findings suggested (rs911160) (rs2289590) affect Further validation studies larger multi-ethnical populations are needed elucidate their functional impact on GC. Environ. Mol. Mutagen. 58:701-711, 2017. © 2017 Wiley Periodicals, Inc.
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