Lentiviral Diseases of Sheep and Goats: Chronic Pneumonia Leukoencephalomyelitis and Arthritis

摘要: This review describes the pathogenesis of a slowly progressive disease complex caused by naturally occurring nononcogenic retroviruses in sheep and goats. In nature, infections are usually clinically silent, but may manifest itself after prolonged incubation periods. Clinically, this is seen as dyspnea, paralysis, and/or arthritis. all organs basic lesion inflammatory with infiltration proliferation lymphocytes, plasma cells, macrophages. Other organ-specific pathologic changes such primary demyelination central nervous system degeneration cartilaginous structures joints accompany inflammation. The viruses infect tissue-specific macrophage populations vivo. Viral replication these cells restricted to minimal levels continues indefinitely animal result either failure induce specific neutralizing antibodies or antigenic drift when develop. Consistent low-grade viral sets pace for providing continuous stimulation cellular immune response that localize target tissues. These complexes have adverse effects on indigenous cell populations.