Identification of abnormal chromosomal complement in formalin‐fixed, paraffin‐embedded placental tissue
作者： Tracy A. Cowles , Frederick F. B. Elder , Suzanne Taylor
关键词:
摘要: The objective of this project was to assess the efficacy fluorescence in situ hybridization (FISH) with chromosome-specific DNA probes identify chromosome number formalin-fixed, paraffin-embedded placental specimens. Using approach, 75 per cent karyotypes 20 formalin-fixed samples (comprising aneuploids, triploids, and normals) were correctly identified. As technology improves, ability obtain information regarding chromosomal abnormalities tissue should improve as well. This can potentially provide important cytogenetic even when fresh is not available for standard karyotypic analysis.
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