Speeding stroke recovery? A systematic review of amphetamine after stroke.

摘要: Abstract Introduction The use of drugs to enhance recovery (“rehabilitation pharmacology”) has been assessed. Amphetamine can improve outcome in experimental models stroke, and several small clinical trials have assessed its stroke. Methods Electronic searches were performed identify randomised controlled amphetamine stroke (ischaemic or haemorrhagic). Outcomes included functional (assessed as combined death disability/dependency), safety (death) haemodynamic measures. Data analysed dichotomous continuous outcomes, using odds ratios (OR), weighted standardised mean difference, (WMD SMD) random-effects with 95% confidence intervals (95% CI); statistical heterogeneity was Results Eleven completed (n = 329) identified. Treatment associated non-significant trends increased (OR 2.78 CI, 0.75–10.23), n = 329, 11 trials) improved motor scores 3.28 CI − 0.48–7.04) n = 257, 9 but had no effect on the dependency 1.15 0.65–2.06, n = 206, 5 trials). systolic blood pressure 9.3 mmHg, 3.3–15.3, n = 106, 3 heart rate 7.6 beats per minute (bpm), 1.8–13.4, Despite variations treatment regimes, outcomes follow-up duration there evidence significant publication bias. Conclusion No exists at present support after a trend function, doubts remain over are effects, consequences which unknown.