Methamphetamine Potentiates Ischemia/Reperfusion Insults After Transient Middle Cerebral Artery Ligation
作者： Yun Wang , Teruo Hayashi , Chen-Fu Chang , Yung-Hsiao Chiang , Li-I Tsao
关键词: Cerebral blood flow 、 Pharmacology 、 Middle cerebral artery 、 Neurotrophic factors 、 Chloral hydrate 、 Brain damage 、 Medicine 、 Methamphetamine 、 Ischemia 、 Glial cell line-derived neurotrophic factor 、 Anesthesia
摘要: Background and Purpose—Previous studies have indicated that both methamphetamine (MA) ischemia/reperfusion injuries involve reactive oxygen species formation activation of apoptotic mechanism. That MA could a synergistic or additive effect with stroke-induced brain damage is possible. The purpose the present study was to investigate whether administration in vivo would potentiate ischemic injury. Methods—Adult CD-1 mice were pretreated saline. Each animal later anesthetized chloral hydrate placed stereotaxic frame. A subset animals received intracerebral glial cell line–derived neurotrophic factor (GDNF). right middle cerebral artery bilateral carotids transiently occluded for 45 minutes. Regional blood flow measured by laser Doppler. Animals sacrificed triphenyltetrazolium chloride staining p53 mRNA Northern blot assay after 24 hours reperfusion. Cortical striatal GDNF levels a...
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