Transgelin 2 Promotes Paclitaxel Resistance, Migration, and Invasion of Breast Cancer by Directly Interacting with PTEN and Activating PI3K/Akt/GSK-3β Pathway.
作者： Ruifang Hao , Yan Yan , Siying Chen , Haisheng You , Jianfeng Xing
DOI: 10.1158/1535-7163.MCT-19-0261
关键词:
摘要: MDR and tumor migration invasion are still the main obstacles to effective breast cancer chemotherapies. Transgelin 2 has recently been shown induce drug resistance, migration, invasion. The aim of this study was determine biological functions mechanism underlying how induces paclitaxel (PTX) resistance cancer. We detected that protein level significantly upregulated in tissues compared with adjacent nontumor tissues. A bioinformatics analysis indicated related clinicopathologic parameters patient prognosis. Overexpression enhanced human cells decreased sensitivity paclitaxel. Meanwhile, tumorigenesis metastasis were also by overexpression vivo. Moreover, activated PI3K/Akt/GSK-3β pathway increasing phosphorylation levels Akt GSK-3β decreasing expression PTEN. found could directly interact PTEN located upstream Furthermore, PI3K/Akt inhibitor MK-2206 reversed inhibited cells. These findings indicate promotes interacting activating pathway. may therefore be useful as a novel biomarker therapeutic target for
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