Antioxidant ability and lipid peroxidation in the hippocampus with epileptogenesis induced by Fe3+ injection into the amygdaloid body of rats
作者： Yuto Ueda , Akira Nakajima , Jun Tokumaru
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摘要: To analyze antioxidant ability and lipid peroxidation in the hippocampus of rats an interictal state FeCl3-induced epileptogenesis, hippocampal eliminating decay ratio exogenously applied nitroxide radical (3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (carbamoyl-PROXYL)) by electron paramagnetic resonance (EPR) spectroscopy, thiobarbituric reactive substances (TBARS) level were measured. The prolonged half-life paramagnetism carbamoyl-PROXYL with chronic epileptogenesis revealed decreased ability, which supports vulnerability against oxidative stress. In addition, TBARS (marker peroxidation) was increased injected FeCl3 compared that control. This study repetitive seizures resulted explained regional to stress limbic system epileptogenesis.
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