Hippocampal gene expression profiling in a rat model of posttraumatic epilepsy reveals temporal upregulation of lipid metabolism-related genes.
作者： Yuto Ueda , Aya Kitamoto , L. James Willmore , Toshio Kojima
DOI: 10.1007/S11064-013-1037-9
关键词:
摘要: Traumatic brain injury occasionally causes posttraumatic epilepsy. To elucidate the molecular events responsible for epilepsy, we established a rodent model that involved injection of microliter quantities FeCl3 solution into amygdalar nuclear complex. We previously compared hippocampal gene expression profiles in traumatic epilepsy and normal rats at 5 days after (acute phase) to determine role inflammation. In this study, focused on later stages epileptogenesis. 5, 15 (sub-chronic phase), 30 (chronic identify temporal changes networks A total 81 genes were significantly (at least twofold) up- or downregulated over course disease progression. found related lipid metabolism, namely, Apoa1, Gh, Mc4r, Oprk1, Pdk4, temporarily upregulated sub-chronic phase. Changes metabolism regulation might be seizure propagation during This description throughout epileptogenesis provides clues potential markers phases new therapeutic targets.
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sci-hub.se 参考文章(12)
Yuto Ueda, Akira Nakajima, Jun Tokumaru, Antioxidant ability and lipid peroxidation in the hippocampus with epileptogenesis induced by Fe3+ injection into the amygdaloid body of rats Neurochemical Research. ,vol. 28, pp. 1895- 1900 ,(2003) , 10.1023/A:1026136211759
L. J. Willmore, Yuto Ueda, Posttraumatic Epilepsy: Hemorrhage, Free Radicals and the Molecular Regulation of Glutamate Neurochemical Research. ,vol. 34, pp. 688- 697 ,(2009) , 10.1007/S11064-008-9841-3
John Ford, Fabio Rupp, Julio Mulero, Bryan Boyle, Shannon Bradley, Jessica Bright, Sarah Nelken, Tam Ho, Nancy Mize, John Childs, Dennis Ballinger, Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP) Immunogenetics. ,vol. 54, pp. 293- 300 ,(2002) , 10.1007/S00251-002-0467-3
Daniele Piomelli, Giuseppe Astarita, Rao Rapaka, A neuroscientist's guide to lipidomics Nature Reviews Neuroscience. ,vol. 8, pp. 743- 754 ,(2007) , 10.1038/NRN2233
Keiko Kato, Masakazu Suzuki, Hiroki Kanno, Shinji Sekino, Ken Kusakabe, Toshiya Okada, Tetsuji Mori, Kazuyuki Yoshida, Yoshio Hirabayashi, Distinct role of growth hormone on epilepsy progression in a model of temporal lobe epilepsy Journal of Neurochemistry. ,vol. 110, pp. 509- 519 ,(2009) , 10.1111/J.1471-4159.2009.06132.X
L. James Willmore, R.W. Hurd, George W. Sypert, Epileptiform activity initiated by pial iontophoresis of ferrous and ferric chloride on rat cerebral cortex. Brain Research. ,vol. 152, pp. 406- 410 ,(1978) , 10.1016/0006-8993(78)90273-1
Nicole Ruiz, Luis F. Pacheco, Bianca Farrell, Cody B. Cox, Boris S. Ermolinsky, Emilio R. Garrido-Sanabria, Saraswathy Nair, Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy Brain Research. ,vol. 1426, pp. 86- 95 ,(2011) , 10.1016/J.BRAINRES.2011.10.006
H. PAYAN, M. TOGA, M. BÉRARD-BADIER, The Pathology of Post‐Traumatic Epilepsies Epilepsia. ,vol. 11, pp. 81- 94 ,(1970) , 10.1111/J.1528-1157.1970.TB03869.X
L. James Willmore, Post-traumatic epilepsy: cellular mechanisms and implications for treatment. Epilepsia. ,vol. 31, ,(1990) , 10.1111/J.1528-1157.1990.TB05861.X
Yuto Ueda, Aya Kitamoto, L. J. Willmore, Toshio Kojima, Hippocampal gene network analysis in an experimental model of posttraumatic epilepsy. Neurochemical Research. ,vol. 36, pp. 1323- 1328 ,(2011) , 10.1007/S11064-010-0386-X