Clinical and Biochemical Assessments of Circulating B-Type Natriuretic Peptide as a Useful Marker in Pediatric Cardiac Patients

摘要: Background Although the left ventricle is major site of BNP secretion in response to cardiac pressure or volume overload, myocytes both atria and ventricles secrete B- type natriuretic peptide (BNP). This study aimed assess compare plasma levels common pediatric diseases clarify its pathophysiological role evaluate possible diagnostic prognostic utility patients with congenital heart disease (CHD), failure (HF). Materials Methods: The a prospective, case-control research including 131 selected from Pediatric Department South Valley University Hospitals Qena, Egypt, variety 70 healthy controls. were categorized into 4 groups: 61 newly diagnosed CHD, 30 HF, 20 cardiomyopathy (CM), children rheumatic (RHD). Clinical echocardiographic assessments for performed. Bioassays using commercially available ELISA assay kits performed participants. Results: median significantly higher HF CM groups than RHD control groups, p Conclusion validity diagnosing was superior predicting CHD among patients.