Photodynamic therapy with verteporfin to induce regression of aggressive retinal astrocytomas.
作者： Sebastian Eskelin , Petri Tommila , Tapani Palosaari , Tero Kivelä
DOI: 10.1111/J.1755-3768.2007.01151.X
关键词:
摘要: . Purpose: To evaluate the effect of photodynamic therapy (PDT) with verteporfin on symptomatic, aggressive retinal astrocytomas. Methods: A prospective, interventional study in a tertiary referral centre. Two patients were treated single session PDT using standard parameters Verteporfin Photodynamic Therapy (VIP) study: 34-year-old man whose previously stationary juxtapapillary astrocytoma, secondary to tuberous sclerosis, progressed within 7 months involve foveola; and 68-year-old acquired astrocytoma over 18 months spite photocoagulation. Both tumours vascularized had caused lipid exudation an exudative detachment. Outcome measures visual acuity, resorption subretinal fluid, tumour height fluorescein angiography. Results: The progressing, part both astrocytomas regressed, little change poorly vascularized, congenital hamartoma. Visual acuity improved first patient was unchanged second by 3 months, stable vision no sign recurrence at 2 years. detachments resolved completely. Tumour reduced median 30%. Regression associated obliteration vessels progressing lesion, closure some dilated capillaries tumour. Intraretinal microvascular abnormalities scattered haemorrhages appeared outside area patient. Conclusion: can induce regression progressive, may prevent typical progression total detachment enucleation, whether is sclerosis or not. be considered first-line treatment for astrocytomas.
sci-hub.se 参考文章(24)
Brian P Marr, Carol L Shields, Ralph C Eagle, Jerry A Shields, AGGRESSIVE RETINAL ASTROCYTOMAS IN FOUR PATIENTS WITH TUBEROUS SCLEROSIS COMPLEX Transactions of the American Ophthalmological Society. ,vol. 102, pp. 139- ,(2004)
James R Coppeto, Daniel M Albert, Jane R Lubin, Astrocytic hamartoma in tuberous sclerosis mimicking necrotizing retinochoroiditis. Journal of Pediatric Ophthalmology & Strabismus. ,vol. 19, pp. 306- 313 ,(1982) , 10.3928/0191-3913-19821101-07
J Arnold, D Kilmartin, J Olson, S Neville, K Robinson, A Laird, C Richmond, A Farrow, S McKay, DA Saperstein, TM Aaberg, JB Johnson, R Waldron, D Loupe, J Gillman, B Myles, AP Schachat, NM Bressler, SB Bressler, P Nesbitt, T Porter, P Hawse, M Hartnett, A Eager, J Belt, D Cain, D Emmert, T George, M Herring, J McDonald, J Mones, B Corcostegui, M Gilbert, N Duran, M Sisquella, A Nolla, A Margalef, JW Miller, ES Gragoudas, AM Lane, N Emmanuel, A Holbrook, C Evans, US Lord, DK Walsh, CD Callahan, JL DuBois, H Lewis, PK Kaiser, LJ Holody, E Lesak, S Lichterman, H Siegel, A Fattori, G Ambrose, T Fecko, D Ross, S Burke, L Singerman, H Zegarra, M Novak, M Bartel, K Tilocco-DuBois, M Iic, S Schura, SJ Mayes, V Tanner, P Rowe, S Smith-Brewer, D Kukula, G Greanoff, G Daley, J DuBois, D Lehnhardt, GE Fish, BF Jost, R Anand, D Callanan, S Arceneaux, J Arnwine, P Ellenich, J King, H Aguado, R Rollins, B Jurklies, D Pauleikhoff, A Hintzmann, M Fischer, C Sowa, E Behne, CJ Pournaras, G Donati, AD Kapetanios, K Cavaliere, S Guney-Wagner, N Gerber, M Sickenberg, V Sickenberg, A Gans, B Hosner, A Sbressa, C Kozma, M Curchod, SA Cancelli, S Harding, YC Yang, M Briggs, S Briggs, V Tompkin, R Jackson, S Pearson, S Natha, J Sharp, JI Lim, C Flaxel, M Padilla, L Levin, F Walonker, L Cisneros, T Nichols, U Schmidt-Erfurth, I Barbazetto, H Laqua, R Kupfer, R Bulow, B Glisovic, T Bredfeldt, H Elsner, V Wintzer, D Bahlmann, S Michels, MS Blumenkranz, HL Little, R Jack, LM Espiritu, L Unyi, J Regan, L Lamborn, C Silvestri, RH Rosa, PJ Rosenfeld, ML Lewis, B Rodriguez, A Torres, N Munoz, T Contreras, M Galvez, D Hess, T Cubillas, I Rams, None, Photodynamic therapy of subfoveal choroidal neovascularization in pathologic myopia with verteporfin - 1-year results of a randomized clinical trial - VIP report no. 1 Ophthalmology. ,vol. 108, pp. 841- 852 ,(2001) , 10.1016/S0161-6420(01)00544-9
Antal Szabó, Zsuzsanna Géhl, András Seres, Photodynamic (verteporfin) therapy for retinal capillary haemangioma, with monitoring of feeder and draining blood vessel diameters. Acta Ophthalmologica Scandinavica. ,vol. 83, pp. 512- 513 ,(2005) , 10.1111/J.1600-0420.2005.00476.X
STEPHAN MICHELS, RIKE MICHELS, CHRISTIAN SIMADER, URSULA SCHMIDT-ERFURTH, Verteporfin therapy for choroidal hemangioma: a long-term follow-up. Retina-the Journal of Retinal and Vitreous Diseases. ,vol. 25, pp. 697- 703 ,(2005) , 10.1097/00006982-200509000-00003
Neal H. Atebara, Retinal capillary hemangioma treated with verteporfin photodynamic therapy. American Journal of Ophthalmology. ,vol. 134, pp. 788- 790 ,(2002) , 10.1016/S0002-9394(02)01648-3
Ursula M Schmidt-Erfurth, Christine Kusserow, Irene A Barbazetto, Horst Laqua, Benefits and complications of photodynamic therapy of papillary capillary hemangiomas Ophthalmology. ,vol. 109, pp. 1256- 1266 ,(2002) , 10.1016/S0161-6420(02)01059-X
Stefan Mennel, Carsten H. Meyer, Silvia Peter, Jörg C. Schmidt, Peter Kroll, Current treatment modalities for exudative retinal hamartomas secondary to tuberous sclerosis: review of the literature Acta Ophthalmologica Scandinavica. ,vol. 85, pp. 127- 132 ,(2006) , 10.1111/J.1600-0420.2006.00781.X
INGRID E. ZIMMER-GALLER, DENNIS M. ROBERTSON, Long-term observation of retinal lesions in tuberous sclerosis. American Journal of Ophthalmology. ,vol. 119, pp. 318- 324 ,(1995) , 10.1016/S0002-9394(14)71174-2
Thomas M. Aaberg, Three Cases of Large Retinal Capillary Hemangiomas Treated With Verteporfin and Photodynamic Therapy Archives of Ophthalmology. ,vol. 123, pp. 328- 332 ,(2005) , 10.1001/ARCHOPHT.123.3.328