Methods for rational pegylation of proteins
作者： John Rudolph Desjarlais , Jonathan Zalevsky
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摘要: The present invention relates to the use of simulation technology rationally optimize locations and sizes attached polymeric moieties for modification therapeutic proteins generated from this method.
lens.org参考文章(78)
Steven Henikoff, Jorja G Henikoff, Amino acid substitution matrices Advances in Protein Chemistry. ,vol. 54, pp. 73- 97 ,(2000) , 10.1016/S0065-3233(00)54003-0
Yuping Cai, Alexander N. Glazer, Aaron J. Tooley, Engineering of living cells for the expression of holo-phycobiliprotein-based constructs ,(2002)
Hansruedi Lotscher, David Banner, Dietrich Stuber, Werner Lesslauer, Tumor necrosis factor muteins ,(1994)
Riichiro Takemura, Tomonori Sekiguchi, Katsutaka Kimura, Tsugio Takahashi, Kazuhiko Kajigaya, Yoshitaka Nakamura, Dynamic random access memory (DRAM) capable of canceling out complementary noise developed in plate electrodes of memory cell capacitors ,(2005)
Timothy D. Bartley, Pamela Hunt, Babru B. Samal, Robert A. Bosselman, Jakob M. Bogenberger, Olaf B. Kinstler, Method for treating mammals with monopegylated proteins that stimulates megakaryocyte growth and differentiation Official Gazette of the United States Patent and Trademark Office Patents. ,vol. 1211, pp. 2787- ,(1995)
Jay W. Ponder, Frederic M. Richards, Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structural classes. Journal of Molecular Biology. ,vol. 193, pp. 775- 791 ,(1987) , 10.1016/0022-2836(87)90358-5
Irene Luque, Ernesto Freire, Method for the prediction of binding targets and the design of ligands ,(2000)
Olaf Kinstler, Colin Gegg, Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility ,(1999)
John R. Desjarlais, Apparatus and method for designing proteins and protein libraries ,(2002)
Anton Filikov, Umesh Muchhal, Malu Lourdes G. Tansey, John R. Desjarlais, Bassil I. Dahiyat, Jonathan Zalevsky, TNF-alpha VARIANTS PROTEINS FOR THE TREATMENT OF TNF-alpha RELATED DISORDERS ,(2007)