Comparison of three commercial one-dose porcine circovirus type 2 (PCV2) vaccines in a herd with concurrent circulation of PCV2b and mutant PCV2b.
作者： Jiwoon Jeong , Changhoon Park , Kyuhyung Choi , Chanhee Chae
DOI: 10.1016/J.VETMIC.2015.02.027
关键词:
摘要: Porcine circovirus associated disease (PCVAD) occurred in a farm where pigs had been routinely vaccinated with commercial PCV2a vaccine. A mutant PCV2b (mPCV2b) was isolated from PCVAD, perhaps implying perceived vaccine failure. The objective of this study to determine and compare the efficacy 3 one-dose vaccines varying antigen type dose same pig concurrent mPCV2b infection based on clinical (average daily weight gain; ADWG), virological (evidence viremia), immunological (presence PCV2-specific neutralizing antibody; NA interferon-γ secreting cells; IFN-γ-SC), pathological (lymphoid lesion PCV2 score within lesion) evaluation. Regardless which used, animals improved ADWG, reduced amount load blood compared unvaccinated animals. vaccination piglets at weeks age effectively induced higher levels PCV2b- mPCV2b-specific IFN-γ-SC reduction coincided appearance both microscopic lymphoid lesions PCV2-antigen scores lymph nodes were significantly lower failure could not be explained by incomplete protection against mPCV2b. results present demonstrated that currently available are protective clinical, virological, immunological, evaluations under field conditions.
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