Choline dietary supplementation improves LiCl-induced context aversion retention in adult rats.

摘要: Abstract Previous studies have demonstrated that choline is an essential nutrient during prenatal and early postnatal developmental periods. Thus, the availability of these periods produces some beneficial effects on hippocampal-dependent learning memory in rats. However, research effect adult supplementation abilities scarce. In present study, 3–4 month-old male Wistar rats receiving a 7-week choline-supplemented diet (4.5 fold standard diet) control were trained LiCl-induced contextual aversion task. Short long-term context retention was assessed by recording consumption flavoured solution aversive safe contexts over two subsequent tests. Statistical analysis showed supplemented group exhibited greater intake suppression than when tests applied 3 15 days after conditioning. These results suggest increasing dietary adulthood may favour aversion.