One-carbon metabolism in neurodevelopmental disorders: using broad-based nutraceutics to treat cognitive deficits in complex spectrum disorders.

摘要: Folate and choline, two nutrients involved in the one-carbon metabolic cycle, are intimately regulating DNA integrity, synthesis, biogenic amine methylation. In this review, we discuss evidence that folate choline play an important role normal cognitive development, altered levels of these during periods high neuronal proliferation synaptogenesis can result diminished function. We also use as therapeutic agents a spectrum developmental disorders which intellectual disability is prominent feature, such Fragile-X, Rett syndrome, Down Autism disorders. A survey recent literature suggests nutritional supplements have mild, but generally consistent, effects on improving cognition. Intervening with earlier rather than later development more effective outcomes. Given mild improvements seen after treatments using alone, importance genetic profile parents offspring, suggest nutraceutics early combination other therapeutics likely to positive impacts outcomes broad complex neurodevelopmental