Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas

作者: Yoshikazu Okamoto , Pier-Luigi Di Patre , Christoph Burkhard , Sonja Horstmann , Benjamin Jourde

DOI: 10.1007/S00401-004-0861-Z

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摘要: We carried out a population-based study on low-grade diffuse gliomas in the Canton of Zurich, Switzerland (population 1.16 million). From 1980 to 1994, 987 astrocytic and oligodendroglial tumors were diagnosed, which 122 (12.4%) (WHO grade II). The incidence rates adjusted World Standard Population, per million population year, 2.28 for astrocytomas, 0.89 oligoastrocytomas, 2.45 oligodendrogliomas. survival rate (mean follow-up 7.5+/-4.8 years) was highest patients with oligodendroglioma (78% at 5 years, 51% 10 years), followed by those oligoastrocytoma (70% 49% fibrillary astrocytoma (65% 31% years). Survival gemistocytic poor, 16% years 0% years. Younger ( 50 years; P=0.013). DNA sequencing, performed 84% cases, revealed that TP53 mutations most frequent astrocytomas (88%), (53%) oligoastrocytomas (44%), but infrequent (13%) presence associated shorter (log-rank test; P=0.047), when each histological type analyzed separately, an association observed only P=0.05). Loss 1p 19q assessed quantitative microsatellite analysis 67% cases. These alterations oligodendrogliomas (1p, 57%; 19q, 69%), less common 27%; 45%), rare 7%; 7%), absent astrocytomas. None these predictive survival. results establish frequency key genetic level. Multivariate Cox's regression indicates age type, not alterations, are significant factors.

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