Fluctuations in symptoms in human immunodeficiency virus-infected children: the first 10 years of life.

摘要: Objective. To describe patterns of clinical and immunologic progression in children who are vertically infected with the human immunodeficiency virus.Methods. Children were born to mothers virus 11 European centers enrolled at birth a prospective study followed according standard protocol. At each visit, class was allocated guidelines Centers for Disease Control Prevention (CDC). Progression serious disease death assessed, allowing available actual antiretroviral therapy (ART). CDC visit assessed cross-sectionally.Results. More than 15% will have progressed category C or by age 1 year nearly 50% 10 years. Just under 20% evidence severe 75% In general, immune status poorly reflected condition. after 1994, when recommendation earlier initiation more active introduced, significantly less likely progress those treatment not widely largely confined zidovudine monotherapy. Estimated initially faster untreated treated children, but years estimated cumulative similar both groups. Treatment started before associated slower progression. Cross-sectional analysis showed that symptom-free throughout their lives. After 4 age, fewer 25% had symptoms any one time, irrespective ART received.Conclusion. Vertically without signs most time. The prognosis has improved widespread availability use combination ART. These findings implications health, education, other support-service provision.