Overexpression of toll-like receptor 3 in spleen is associated with experimental arthritis in rats.

摘要: This study is to investigate the regulation of Toll-like receptor (TLR) expression in systemic immune reactions different arthritis rat models, which will provide evidence understand mechanisms rheumatoid further. Arthritis-susceptible DA rats were used induce by pristane or collagen type II, and TLR2, 3, 4 7 levels spleen detected real-time quantitative polymerase chain reaction. TLR3 mRNA both collagen-induced pristane-induced (PIA) was increased significantly at 26 70 days after induction. The overexpression confirmed Western blotting. Methotrexate administrated peritoneally PIA rats, phytol applied subcutaneously rats. Both methotrexate treatment could alleviate severity block However, arthritis-resistant E3 injected with pristane, unaltered. MHC congenic DA.1U had mild symptoms, whereas showed an impaired induction D26. So we conclude that splenic strongly associated suggests should be a most vital TLR regulate initiation development experimental may as intriguing therapeutic opportunity for human arthritis.