Pristane induces autophagy in macrophages, promoting a STAT1-IRF1-TLR3 pathway and arthritis
作者： Wenhua Zhu , Jing Xu , Congshan Jiang , Bo Wang , Manman Geng
DOI: 10.1016/J.CLIM.2016.11.017
关键词:
摘要: Autophagy is involved in both innate and adaptive immune regulation. We propose that autophagy regulates activation of TLR3 macrophages thereby essential for development pristane-induced arthritis. found pristane treatment induced vitro vivo, spleen cells from injected rats. The was associated with STAT1 phosphorylation expression IRF1 TLR3. Blocking the activated by Wortmannin Bafilomycin A1 or RNAi Becn1 led to a downregulation STAT1-IRF1-TLR3 pathway. Most importantly, arthritis alleviated suppressing either conclude enhanced autophagy, leading STAT1-IRF1 controlled upregulation macrophages, pathogenic mechanism
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