Regenerating gene I regulates interleukin-6 production in squamous esophageal cancer cells
作者： Shuetsu Usami , Satoru Motoyama , Souichi Koyota , Jingshu Wang , Kaori Hayashi-Shibuya
DOI: 10.1016/J.BBRC.2009.12.129
关键词:
摘要: Abstract Regenerating gene (REG) I plays important roles in cancer cell biology. The purpose of this study was to determine whether REG affects cytokine production cells. We transfected TE-5 and TE-9 squamous esophageal cells with Iα Iβ examined its effects on expression. found that transfecting led significantly increased expression interleukin (IL)-6 mRNA protein, but it had little or no effect IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, IL-17A, interferon-γ, tumor necrosis factor-α, granulocyte-colony stimulating factor transforming growth factor-β1. elevated IL-6 seen transfectants silenced by small interfering RNA-mediated knockdown. These finding suggest may act through exert
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