Negative Regulation of FcεRI-mediated Degranulation by CD81

摘要: Signaling through the high affinity receptor for immunoglobulin E (FceRI) results in coordinate activation of tyrosine kinases before calcium mobilization. Receptors capable interfering with signaling antigen receptors, such as FceRI, recruit and inositol phosphatases that diminished Here, we show antibodies recognizing CD81 inhibit FceRI-mediated mast cell degranulation but, surprisingly, without affecting aggregation-dependent phosphorylation, mobilization, or leukotriene synthesis. Furthermore, also vivo measured by reduced passive cutaneous anaphylaxis responses. These reveal an unsuspected calcium-independent pathway regulation, which is accessible to engagement membrane proteins on novel therapeutic approaches allergic diseases could be based.