Roles of cyclin D1 and related genes in growth inhibition, senescence and apoptosis.
作者： E. K.-H. Han , S.-C. Ng , N. Arber , M. Begemann , I. B. Weinstein
关键词:
摘要: It is now apparent that apoptosis closely linked to the control of cell cycle progression. During G1 S progression, cyclin D1, p53, and dependent kinase inhibitors p21WAF1 p27kip1 can play roles in induction apoptosis. G2 M phases, premature activation Cdk1 cause cells enter mitotic catastrophe, which results In this review we focus on factors acting during S, particularly their effects growth, senescence We emphasize D1 have diverse depending its level expression, specific type, context other factors. Possible mechanisms by exerts these effects, via kinase-dependent -independent pathways, are discussed.
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