HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort

N. Bradshaw, C. Brewer, G. Brice, B. Bullman, J. Campbell, B. Castle, R. Cetnarsryj, C. Chapman, C. Chu, N. Coates, T. Cole, R. Davidson, A. Donaldson, H. Dorkins, F. Douglas, D. Eccles, R. Eeles, F. Elmslie, D. G. Evans, S. Goff, S. Goodman, D. Goudie, J. Gray, L. Greenhalgh, H. Gregory, S. V. Hodgson, T. Homfray, R. S. Houlston, L. Izatt, L. Jackson, L. Jeffers, V. Johnson-Roffey, F. Kavalier, C. Kirk, F. Lalloo, C. Langman, I. Locke, M. Longmuir, J. Mackay, A. Magee, S. Mansour, Z. Miedzybrodzka, J. Miller, P. Morrison, V. Murday, J. Paterson, G. Pichert, M. Porteous, N. Rahman, M. Rogers, S. Rowe, S. Shanley, A. Saggar, G. Scott, L. Side, L. Snadden, M. Steel, M. Thomas, S. Thomas, M. I. McCarthy, A. T. Hattersley, , E. Zeggini, M. N. Weedon, C. M. Lindgren, T. M. Frayling, K. S. Elliott, H. Lango, N. J. Timpson, J. R. B. Perry, N. W. Rayner, R. M. Freathy, J. C. Barrett, B. Shields, A. P. Morris, S. Ellard, C. J. Groves, L. W. Harries, J. L. Marchini, K. R. Owen, B. Knight, L. R. Cardon, M. Walker, G. A. Hitman, A. D. Morris, A. S. F. Doney, P. R. Burton, D. G. Clayton, N. Craddock, P. Deloukas, A. Duncanson, D. P. Kwiatkowski, W. H. Ouwehand, N. J. Samani, J. A. Todd, P. Donnelly, D. Davison, D. Easton, D. Evans, H.-T. Leung, C. C. A. Spencer, M. D. Tobin, A. P. Attwood, J. P. Boorman, B. Cant, U. Everson, J. M. Hussey, J. D. Jolley, A. S. Knight, K. Koch, E. Meech, S. Nutland, C. V. Prowse, H. E. Stevens, N. C. Taylor, G. R. Walters, N. M. Walker, N. A. Watkins, T. Winzer, R. W. Jones, W. L. McArdle, S. M. Ring, D. P. Strachan, M. Pembrey, G. Breen, D. St. Clair, S. Caesar, K. Gordon-Smith, L. Jones, C. Fraser, E. K. Green, D. Grozeva, M. L. Hamshere, P. A. Holmans, I. R. Jones, G. Kirov, V. Moskvina, I. Nikolov, M. C. O'Donovan, M. J. Owen, D. A. Collier, A. Elkin, A. Farmer, R. Williamson, P. McGuffin, A. H. Young, I. N. Ferrier, S. G. Ball, A. J. Balmforth, J. H. Barrett, D. T. Bishop, M. M. Iles, A. Maqbool, N. Yuldasheva, A. S. Hall, P. S. Braund, R. J. Dixon, M. Mangino, S. Stevens, J. R. Thompson, F. Bredin, M. Tremelling, M. Parkes, H. Drummond, C. W. Lees, E. R. Nimmo, J. Satsangi, S. A. Fisher, A. Forbes, C. M. Lewis, C. M. Onnie, N. J. Prescott, J. Sanderson, C. G. Mathew, J. Barbour, M. K. Mohiuddin, C. E. Todhunter, J. C. Mansfield, T. Ahmad, F. R. Cummings, D. P. Jewell, J. Webster, M. J. Brown, G. M. Lathrop, J. Connell, A. Dominiczak, C. A. Braga Marcano, B. Burke, R. Dobson, J. Gungadoo, K. L. Lee, P. B. Munroe, S. J. Newhouse, A. Onipinla, C. Wallace, M. Xue, M. Caulfield, M. Farrall, A. Barton, I. N. Bruce, H. Donovan, S. Eyre, P. D. Gilbert, S. L. Hider, A. M. Hinks, S. L. John, C. Potter, A. J. Silman, D. P. M. Symmons, W. Thomson, J. Worthington, D. B. Dunger, B. Widmer, M. Newport, G. Sirugo, E. Lyons, F. Vannberg, A. V. S. Hill, L. A. Bradbury, C. Farrar, J. J. Pointon, P. Wordsworth, M. A. Brown, J. A. Franklyn, J. M. Heward, M. J. Simmonds, S. C. L. Gough, S. Seal, M. R. Stratton, N. Rahman, M. Ban, A. Goris, S. J. Sawcer, A. Compston, D. Conway, M. Jallow, K. A. Rockett, S. J. Bumpstead, A. Chaney, K. Downes, M. J. R. Ghori, R. Gwilliam, S. E. Hunt, M. Inouye, A. Keniry, E. King, R. McGinnis, S. Potter, R. Ravindrarajah, P. Whittaker, C. Widden, D. Withers, N. J. Cardin, T. Ferreira, J. Pereira-Gale, I. B. Hallgrimsdottir, B. N. Howie, Z. Su, Y. Y. Teo, D. Vukcevic, D. Bentley, A. Compston, N. J. Ouwehand, M. R. Samani, J. D. Isaacs, A. W. Morgan, G. D. Wilson, A. Ardern-Jones, J. Berg, A. Brady, Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes Science. ,vol. 316, pp. 1336- 1341 ,(2007) , 10.1126/SCIENCE.1142364

Struan F A Grant, Gudmar Thorleifsson, Inga Reynisdottir, Rafn Benediktsson, Andrei Manolescu, Jesus Sainz, Agnar Helgason, Hreinn Stefansson, Valur Emilsson, Anna Helgadottir, Unnur Styrkarsdottir, Kristinn P Magnusson, G Bragi Walters, Ebba Palsdottir, Thorbjorg Jonsdottir, Thorunn Gudmundsdottir, Arnaldur Gylfason, Jona Saemundsdottir, Robert L Wilensky, Muredach P Reilly, Daniel J Rader, Yu Bagger, Claus Christiansen, Vilmundur Gudnason, Gunnar Sigurdsson, Unnur Thorsteinsdottir, Jeffrey R Gulcher, Augustine Kong, Kari Stefansson, Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nature Genetics. ,vol. 38, pp. 320- 323 ,(2006) , 10.1038/NG1732

U. Smith, TCF7L2 and type 2 diabetes--we WNT to know. Diabetologia. ,vol. 50, pp. 5- 7 ,(2006) , 10.1007/S00125-006-0521-Z

J. V. van Vliet-Ostaptchouk, R. Shiri-Sverdlov, A. Zhernakova, E. Strengman, T. W. van Haeften, M. H. Hofker, C. Wijmenga, Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort Diabetologia. ,vol. 50, pp. 59- 62 ,(2007) , 10.1007/S00125-006-0477-Z

Roque Bort, Juan Pedro Martinez-Barbera, Rosa SP Beddington, Kenneth S Zaret, Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development. ,vol. 131, pp. 797- 806 ,(2004) , 10.1242/DEV.00965

Alienke J Monsuur, Paul I W de Bakker, Behrooz Z Alizadeh, Alexandra Zhernakova, Marianna R Bevova, Eric Strengman, Lude Franke, Ruben van't Slot, Martine J van Belzen, Ineke C M Lavrijsen, Begoña Diosdado, Mark J Daly, Chris J J Mulder, M Luisa Mearin, Jos W R Meijer, Gerrit A Meijer, Erica van Oort, Martin C Wapenaar, Bobby P C Koeleman, Cisca Wijmenga, Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect Nature Genetics. ,vol. 37, pp. 1341- 1344 ,(2005) , 10.1038/NG1680

Robert Sladek, Ghislain Rocheleau, Johan Rung, Christian Dina, Lishuang Shen, David Serre, Philippe Boutin, Daniel Vincent, Alexandre Belisle, Samy Hadjadj, Beverley Balkau, Barbara Heude, Guillaume Charpentier, Thomas J. Hudson, Alexandre Montpetit, Alexey V. Pshezhetsky, Marc Prentki, Barry I. Posner, David J. Balding, David Meyre, Constantin Polychronakos, Philippe Froguel, A genome-wide association study identifies novel risk loci for type 2 diabetes Nature. ,vol. 445, pp. 881- 885 ,(2007) , 10.1038/NATURE05616

S. B. Gabriel, G.-W. Chirn, Q. Ma, H. Parikh, D. Richardson, D. Ricke, S. Purcell, , R. Saxena, B. F. Voight, V. Lyssenko, N. P. Burtt, P. I. W. de Bakker, H. Chen, J. J. Roix, S. Kathiresan, J. N. Hirschhorn, M. J. Daly, T. E. Hughes, L. Groop, D. Altshuler, P. Almgren, J. C. Florez, J. Meyer, K. Ardlie, K. Bengtsson Bostrom, B. Isomaa, G. Lettre, U. Lindblad, H. N. Lyon, O. Melander, C. Newton-Cheh, P. Nilsson, M. Orho-Melander, L. Rastam, E. K. Speliotes, M.-R. Taskinen, T. Tuomi, C. Guiducci, A. Berglund, J. Carlson, L. Gianniny, R. Hackett, L. Hall, J. Holmkvist, E. Laurila, M. Sjogren, M. Sterner, A. Surti, M. Svensson, M. Svensson, R. Tewhey, B. Blumenstiel, M. Parkin, M. DeFelice, R. Barry, W. Brodeur, J. Camarata, N. Chia, M. Fava, J. Gibbons, B. Handsaker, C. Healy, K. Nguyen, C. Gates, C. Sougnez, D. Gage, M. Nizzari, Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels Science. ,vol. 316, pp. 1331- 1336 ,(2007) , 10.1126/SCIENCE.1142358

Lude Franke, Harm van Bakel, Like Fokkens, Edwin D. de Jong, Michael Egmont-Petersen, Cisca Wijmenga, Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes. American Journal of Human Genetics. ,vol. 78, pp. 1011- 1025 ,(2006) , 10.1086/504300

W. Farris, S. Mansourian, Y. Chang, L. Lindsley, E. A. Eckman, M. P. Frosch, C. B. Eckman, R. E. Tanzi, D. J. Selkoe, S. Guenette, Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 4162- 4167 ,(2003) , 10.1073/PNAS.0230450100