Adhesion Mechanisms in Liver Metastasis

摘要: The liver is a major target organ for metastasis formation by many tumor types, including lung carcinoma (1). aim of the present study elucidation mechanisms underlying interactions between cells and cells, which lead to incorporation cell into tissue, thus enable metastatic tumor. approach was, first observe electron microscopy invasion intact liver, both in vivo perfused situ; second, isolate reproduce that had been observed vivo, addition short-term cultures these cells; third, perturbing vitro interations mainly antibodies directed against either or cells. studies indicated mechanism was qualitatively comparable different types although large quantitative differences were seen particularly between, on one hand, diffusely infiltrating lymphoma and, other gave rise nodular metastases. In contrast, experiments clearly showed at molecular level quite distinct, as compared cacinoma