Cytokines and metabolic dysfunction after severe head injury

摘要: ABSTRACT Patients with head injury must overcome central as well peripheral metabolic insults. In addition to specific tissue damage the brain, a cellular biochemical cascade occurs that can negatively affect organ function, cause systemic response injury, and may secondary injury. The metabolites involved in this are numerous complex. Cytokines important cell-to-cell communication mediators during It is speculated cytokines, such interleukin 1 (IL-1), 6 (IL-6), tumor necrosis factor (TNF), 8 (IL-8), which found elevated amounts both human basic trials after play role of Some events produced by small doses cytokine infusion animals, humans, include fever, neutrophilia, muscle breakdown, altered amino acid metabolism, depression serum zinc levels, production hepatic acute phase reactants, increased endothelial permeability, ...