Serum estradiol-17β, progesterone and respective uterine cytosol receptor concentrations in bitches with spontaneous pyometra

摘要: The role of serum estradiol-17 beta (E(2)) and progesterone (P(4)) in relation to uterine estrogen (ER) receptors (PR) was investigated canine cystic endometrial hyperplasia-pyometra (CEH-P). Blood samples were collected pre- post-ovariohysterectomy, respectively, from 54 bitches presenting spontaneous CEH-P 25 healthy control bitches. Competitive enzyme immunoassays (EIA) ligand (ELIA) applied estimate hormones cytosol active receptors, respectively. Animals classified the stages first half diestrus, second diestrus early anestrus on basis reproductive history, clinical signs, ovarian macro- microscopic inspection P(4) concentration. Bitches with CEH-P, compared their respective stage controls, exhibited (a) similar fluctuations, (b) higher E(2) concentrations, (c) lower PR concentrations during (d) ER anestrus. Negative correlation detected between within both groups. It concluded that main receptor regulator for affected uteri. However, bitches, high levels appeared over-activate PRs, leading stronger self-down regulation suppression. These findings indicate an increased sensitivity uterus action. During anestrus, a complementary endogenous considered, since reduction action permit replenishment activation by relatively levels.