Molecular mechanisms of long noncoding RNAs and their role in disease pathogenesis

摘要: // Guoku Hu 1 , Fang Niu Bree A. Humburg Ke Liao Sunil Bendi Shannon Callen Howard S. Fox and Shilpa Buch Department of Pharmacology Experimental Neuroscience, University Nebraska Medical Center, Omaha, NE, USA Correspondence to: Buch, email: sbuch@unmc.edu Hu, guoku.hu@unmc.edu Keywords: long non-coding RNA; CNS disorder; cancer; therapy Received: December 07, 2017      Accepted: January 13, 2018      Published: April 06, 2018 ABSTRACT LncRNAs are regulatory RNAs that longer than 200 nucleotides. One the major functions lncRNAs is regulation specific gene expression at multiple steps including, recruitment basal transcription machinery, post-transcriptional modifications epigenetics [ ]. Emerging evidence suggests also play a critical role in maintaining tissue homeostasis during physiological pathological conditions, lipid homeostasis, as well epithelial smooth muscle cell topic has been elegantly reviewed 2 – 5 While aberrant implicated several disease there paucity information about their contribution to etiology diseases 6 Several studies have compared under normal cancerous conditions found differential lncRNAs, suggesting thereby an involvement processes 7 8 Furthermore, ability influence epigenetic changes underlies pathogenesis since known many human thus not only involved homeostatic functioning but vital progression diseases, underscoring potential novel therapeutic targets for alleviation variety conditions.