Therapeutic potential of neural stem cells: greater in people's perception than in their brains?

摘要: The discovery that the mammalian brain contains neural stem cells, and such cells produce new neurons during adulthood through a process known as “adult neurogenesis,” led to hypothesis their underlying biology could be exploited for central nervous system (CNS) repair purposes. Yet, in spite of large amount knowledge gathered on adult neurogenesis last two decades, no substantial translational advances have been reached most neurological diseases (Rossi Cattaneo, 2002; Arenas, 2010; Lindvall Kokaia, 2010). This may linked intrinsic complexity tissue at structural, developmental, evolutionary level, preclude cell regeneration (Weil et al., 2008; Bonfanti, 2011). As result, replacement is present not possible neither by implementation endogenous neurogenic potential nor transplantation highly sources. However, gold rush-like phenomenon has followed scientific community appeared often unaware limits associated with underestimated some problems hurdles, which remain unknown general public are sometimes undetected scientists themselves. In addition, misleading communication series basic results biased toward translation, along an amplification interpretation from media perception therapeutic “possibilities” were reach. What missed real vision state art: inability medical science fundamental research overcome gap between vitro behavior adaptation environment, well need more prior proposing perspectives. consequence, complex intermix emerging discoveries, scientists' press releases, media, society produced failure results, ultimately putting pressure premature translation still insufficient pre-clinical data. this Opinion article we suggest better public, without distortion themselves, needed avoid misunderstanding increase trust constructive dialogue society.