The quaternary lidocaine derivative, QX-314, produces long-lasting local anesthesia in animal models in vivo.
作者： Tony K. Y. Lim , Bernard A. MacLeod , Craig R. Ries , Stephan K. W. Schwarz
DOI: 10.1097/01.ANES.0000270758.77314.B4
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摘要: … In this study, we have demonstrated that the quaternary lidocaine derivative, QX-314, concentration-dependently and reversibly produced robust local anesthesia of long duration in …
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T Frazier, T Narahashi, M Yamada, THE SITE OF ACTION AND ACTIVE FORM OF LOCAL ANESTHETICS. I. THEORY AND pH EXPERIMENTS WITH TERTIARY COMPOUNDS Journal of Pharmacology and Experimental Therapeutics. ,vol. 171, pp. 32- 44 ,(1970)
Toshio Narahashi, Donald T. Frazier, Minoru Yamada, THE SITE OF ACTION AND ACTIVE FORM OF LOCAL ANESTHETICS. II. EXPERIMENTS WITH QUATERNARY COMPOUNDS Journal of Pharmacology and Experimental Therapeutics. ,vol. 171, pp. 45- 51 ,(1970)
K R Courtney, Structure-activity relations for frequency-dependent sodium channel block in nerve by local anesthetics. Journal of Pharmacology and Experimental Therapeutics. ,vol. 213, pp. 114- 119 ,(1980)
Toshio Narahashi, John W. Moore, Robin N. Poston, Anesthetic blocking of nerve membrane conductances by internal and external applications. Journal of Neurobiology. ,vol. 1, pp. 3- 22 ,(1969) , 10.1002/NEU.480010103
Howard H. Wang, Jay Z. Yeh, Toshio Narahashi, Interaction of spin-labeled local anesthetics with the sodium channel of squid axon membranes The Journal of Membrane Biology. ,vol. 66, pp. 227- 233 ,(1982) , 10.1007/BF01868497
LÁSZLÓ GYERMEK, Quaternary derivatives of benzoyltropine and benzoyl-psi-tropine with anticholinergic and local anaesthetic properties. Nature. ,vol. 171, pp. 788- 788 ,(1953) , 10.1038/171788A0
Benson M. Curtis, James E. Scurlock, The mechanism of action of local anesthesia by tetraethylammonium derivatives. Anesthesiology. ,vol. 54, pp. 270- 277 ,(1981) , 10.1097/00000542-198104000-00003
Peter Gerner, Mustafa Mujtaba, Mohammed Khan, Yukari Sudoh, Kamen Vlassakov, Douglas C. Anthony, Ging Kuo Wang, N-phenylethyl amitriptyline in rat sciatic nerve blockade. Anesthesiology. ,vol. 96, pp. 1435- 1442 ,(2002) , 10.1097/00000542-200206000-00024
Donald N. Franz, Roger S. Perry, Mechanisms for differential block among single myelinated and non-myelinated axons by procaine The Journal of Physiology. ,vol. 236, pp. 193- 210 ,(1974) , 10.1113/JPHYSIOL.1974.SP010430
Frank E. Grubbs, Procedures for Detecting Outlying Observations in Samples Technometrics. ,vol. 11, pp. 1- 21 ,(1969) , 10.1080/00401706.1969.10490657