An attempt to quantitate the contribution of antidiuretic hormone to the diuresis of left atrial distension in conscious dogs

摘要: In order to quantitate the contribution of antidiuretic hormone (ADH) diuresis left atrial distension 52 experiments have been performed in 12 conscious, chronically instrumented beagle dogs. Left pressure was increased by a reversible mitral stenosis about 10 cm H2O (1.0 kPa) for 60 min. Plasma ADH concentration (range between 1.3 and 6.0 pg . ml-1) (radioimmunoassay) decreased every experiment, average decrease being 50%. An i.v. infusion vasopressin (0.05 mU min-1 kg-1) abolished diuretic effect or urine volume below control values; natriuresis not affected. The magnitude dependent on concurrent sodium excretion: when excretion low during distension, more effective reducing than high. It is concluded that mediated (a) suppression (b) factors controlling excretion, these two mechanisms excretion.