Parkinson's disease: 10 years of progress, 1997-2007.

摘要: Many people with Parkinson's disease (PD) and their family members ask physicians "What is happening in research on disease? Is there anything new?" As the initial speaker at symposium organized by Disease Foundation celebration of its 50th anniversary, I sought to address these questions, focusing published between years 1997 2007. cataloged advances considered most important field, recognizing my viewpoint a subjective one likely differs from similar listings that others would put together. Space limitation allows me discuss only tiny fraction remarkable new findings have been discovered during this 10-year span. Nevertheless, expect readers summation field be as impressed am wealth, breadth, excitement stirring PD research. Included overview are highlights both laboratory science clinical In former category knowledge genetics PD; potential etiologic pathogenic causes, especially better understanding endogenous factors within dopaminergic neurons; pathologic changes including deposition alpha-synuclein aggregates; consequences altered degradation proteins ubiquitin-proteasomal pathway lysosome. Clinical has also very active impressively productive advances. information epidemiology PD, awareness additional (besides smoking) might slow onset worsening such caffeine urate; neuroimaging positron emission tomography single photon tomography; keener nonmotor features impact quality life for persons family; recognition behavioral complications medications utilized treat impulse control problems; appreciation natural history increasing impairments relentlessly worsens over time; many controlled trials attempting progression provide symptomatic therapies; surgical approaches alleviate symptoms progression, cellular gene therapy well deep brain stimulation.