Contamination of animal feedingstuffs with undeclared antimicrobial additives

作者: Lorraine Lynas , Deborah Currie , W. John McCaughey , John D. G. McEvoy , D. Glenn Kennedy

DOI: 10.1080/02652039809374626

关键词:

摘要: A study was carried out on 397 feedingstuffs and 11 premixes which 161 (39.5%) were declared free of medication 247 (60.5%) medicated. These subjected to analysis for the presence antibiotics. Of medicated feeds 87 (35.2%) contained undeclared antimicrobials 59 (23.9%) at a concentration sufficient allow quantification by HPLC. unmedicated 71 (44.1%) shown contain detectable 42 (26.1%) concentrations could be quantified The most frequently identified contaminating chlortetracycline (CTC) (15.2%), sulphonamides (6.9%), penicillin (3.4%) ionophores (3.4%). Four samples (ionophores—3, sulphadimidine—1) therapeutic one sample supra‐therapeutic (monensin). remainder sub‐therapeutic. All sulphadimidine detected cause violative tissue residues if fed animals imm...

参考文章(22)
H G Eisenbeis, L J Hanson, S V Givens, Toxic effects of lasalocid in horses. American Journal of Veterinary Research. ,vol. 42, pp. 456- 461 ,(1981)
D. S. H. Sparrow, N. T. Kavanagh, Salinomycin toxicity in pigs. Veterinary Record. ,vol. 127, pp. 507- 507 ,(1990) , 10.1136/VR.127.20.507-A
CT Elliott, JN Campbell, WJ McCaughey, Reduction of sulphadimidine contamination in pig feedingstuffs. Veterinary Record. ,vol. 126, pp. 113- 113 ,(1990) , 10.1136/VR.126.5.113
M P Nikolich, G Hong, N B Shoemaker, A A Salyers, Evidence for natural horizontal transfer of tetQ between bacteria that normally colonize humans and bacteria that normally colonize livestock Applied and Environmental Microbiology. ,vol. 60, pp. 3255- 3260 ,(1994) , 10.1128/AEM.60.9.3255-3260.1994
P. C. Garnsworthy, W. Haresign, J. R. Walton, J. Wiseman, Benefits of antibiotics in animal feed. Recent advances in animal nutrition. pp. 11- 37 ,(1996)
Niall P. Fagan, John D. G. McEvoy, Lorraine Lynas, J. Noel Campbell, W. John McCaughey, Improved recovery of avoparcin from animal feedstuffs using a novel extraction method Analyst. ,vol. 120, pp. 2265- 2268 ,(1995) , 10.1039/AN9952002265
W. John Blanchflower, Robert J. McCracken, Desmond A. Rice, Determination of chlortetracycline residues in tissues using high-performance liquid chromatography with fluorescence detection. Analyst. ,vol. 114, pp. 421- 423 ,(1989) , 10.1039/AN9891400421
F M Aarestrup, P Ahrens, M Madsen, L V Pallesen, R L Poulsen, H Westh, Glycopeptide susceptibility among Danish Enterococcus faecium and Enterococcus faecalis isolates of animal and human origin and PCR identification of genes within the VanA cluster. Antimicrobial Agents and Chemotherapy. ,vol. 40, pp. 1938- 1940 ,(1996) , 10.1128/AAC.40.8.1938
I. KLARE, H. HEIER, H. CLAUS, G. BÖHME, S. MARIN, G. SELTMANN, R. HAKENBECK, V. ANTANASSOVA, W. WITTE, Enterococcus faecium strains with vanA-mediated high-level glycopeptide resistance isolated from animal foodstuffs and fecal samples of humans in the community. Microbial Drug Resistance. ,vol. 1, pp. 265- 272 ,(1995) , 10.1089/MDR.1995.1.265
W. J. McCaughey, C. T. Elliott, S. R. H. Crooks, Determination of sulphadimidine in animal feedstuffs by an enzyme-linked immunoassay. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment. ,vol. 7, pp. 259- 264 ,(1990) , 10.1080/02652039009373890