Pertussis vaccination during pregnancy in Belgium: Results of a prospective controlled cohort study.

摘要: Vaccination during pregnancy has been recommended in some countries as a means to protect young infants from severe infection. Nevertheless, many aspects are still unknown and possible blunting of the infant's immune responses by maternal antibodies, is one concerns with vaccination. We report first prospective controlled cohort study women on effects using Boostrix(®), combined tetanus, diphtheria acellular pertussis vaccine, pregnancy. The primary aim was measure influence this booster dose titer duration presence antibodies assess interference infant responses. In study, 57 pregnant were vaccinated Tdap vaccine (Tetanus Diphtheria Pertussis, Boostrix, GSK Biologicals), at mean gestational age 28.6 weeks. A control group (N=42) received no vaccine. Antibody geometric concentrations (GMCs) against tetanus (TT), (DT), toxin (PT), filamentous haemagglutinin (FHA) pertactin (Prn) measured commercial ELISA tests samples taken preceding vaccination month afterwards, delivery cord blood, before 1 after series 3 containing hexavalent vaccines. Infants born had significantly higher GMC birth 2 months life for all antigens compared offspring unvaccinated women, thereby closing susceptibility gap infants. However, noticed (p<0.001) schedule (weeks 8,12 16). Since already, results support that recommendation provide additional scientific evidence document antibodies.