Interaction of age with lipoproteins as predictors of aortic valve calcification in the multi-ethnic study of atherosclerosis.

摘要: Background Previous epidemiologic studies have shown that low-density lipoprotein is an independent risk factor for prevalent aortic valve calcification (AVC); however, to our knowledge, the interactions between plasma concentrations and age on relative risks (RRs) AVC prevalence severity not been examined in a large, racially ethnically diverse cohort. Methods Using stepwise RR regression, relationships of baseline fasting lipid levels were determined 5801 non–statin-using participants Multi-Ethnic Study Atherosclerosis (MESA). Results In age-stratified, adjusted analyses, lipoprotein–associated RRs (95% confidence intervals) higher younger compared with older (age 45-54 years, 1.69 [1.19-2.39]; 55-64 1.48 [1.24-1.76]; 65-74 1.09 [0.95-1.25]; 75-84 1.16 [0.99-1.36]; P interaction = .04]. There was similar, significant interaction total cholesterol–associated ( interaction = .04). contrast, total- high-density cholesterol ratio similar across all strata interaction = .68). At multivariate no parameter associated severity. Conclusions this diverse, preclinical cohort, only than 65 whereas cholesterol/high-density modest increased ages. These findings may important implications efficacy targets dyslipidemia therapies calcific disease. Trial Registration clinicaltrials.gov Identifier:NCT00005487