Transforming activity of the lymphotoxin-β receptor revealed by expression screening
作者： Shin-ichiro Fujiwara , Yoshihiro Yamashita , Young Lim Choi , Tomoaki Wada , Ruri Kaneda
DOI: 10.1016/J.BBRC.2005.10.080
关键词:
摘要: Pancreatic ductal carcinoma (PDC) remains one of the most intractable human malignancies. To obtain insight into molecular pathogenesis PDC, we constructed a retroviral cDNA expression library with total RNA isolated from PDC cell line MiaPaCa-2. Screening this use focus formation assay NIH 3T3 mouse fibroblasts resulted in identification 13 independent genes transforming activity. One cDNAs thus identified encodes an NH2-terminally truncated form lymphotoxin-β receptor (LTBR). The activity short-type LTBR cells was confirmed by both vitro growth soft agar and vivo tumorigenicity nude mice. full-length (wild-type) protein also found to manifest similar These observations suggest that LTBR, which belongs tumor necrosis factor superfamily proteins, may contribute carcinogenesis.
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