Possible role of collagen reorientation during airway remodeling on mucosal folding

摘要: Airway remodeling in patients with chronic asthma is characterized by thickening and structural change of airway walls. It has been demonstrated previous theoretical models that changes thickness can have an important mechanical effect, particular, on the mucosal folding induced smooth muscle contraction. In this paper, we examine effect collagen fiber orientation folding. The modeled as a two-layer cylindrical tube, submucosa (outer layer) represented isotropic tissue subepithelial layer (inner fiber-reinforced anisotropic tissue. order to follow most recent advancement for modeling material, carry out computation under reduced form strain energy, well energy compatible linear theory infinitesimal strains. We explore effects varying density, strain-stiffening behavior fibers behavior. demonstrate significant impact folding, including critical pressure required induce buckling mode. proper density combined might be strategy used organisms prevent low-mode thus narrowing. Deviation from these balances caused disease status will favor buckling. also find two forms give very similar results, therefore, features still captured form. conclude property may component remodeling.