Sequential Arrival and Graded Secretion of Sema3F by Olfactory Neuron Axons Specify Map Topography at the Bulb
作者： Haruki Takeuchi , Kasumi Inokuchi , Mari Aoki , Fumikazu Suto , Akio Tsuboi
DOI: 10.1016/J.CELL.2010.04.041
关键词:
摘要: In the mouse olfactory system, anatomical locations of sensory neurons (OSNs) roughly correlate with their axonal projection sites along dorsal-ventral (D-V) axis bulb (OB). Here we report that an axon guidance receptor, Neuropilin-2 (Nrp2), and its repulsive ligand, Semaphorin-3F (Sema3F), are expressed by OSNs in a complementary manner is important for establishing map topography. Sema3F secreted early-arriving axons deposited at anterodorsal OB to repel Nrp2-positive arrive later. Sequential arrival OSN as well graded expression Nrp2 help form topographic order D-V axis.
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