The role of the orbitofrontal cortex in normally developing compulsive-like behaviors and obsessive–compulsive disorder

摘要: Mounting evidence concerning obsessive-compulsive disorders points to abnormal functioning of the orbitofrontal cortices. First, patients with disorder (OCD) perform poorly on tasks that rely response suppression/motor inhibition functions mediated by cortex relative both normal and clinical controls. Second, OCD exhibit functional hyperactivity in lateral related structures corresponding symptom severity. In this article, we compare these neurocognitive correlates executive neural underpinnings "compulsive-like" behaviors are common childhood. We discuss phenomenology natural history normative compulsive-like as well behavioral, emotional, cognitive continuities between typical pathological behaviors. then examine associations children's performance deficits their observed characteristics. relate patterns shown adults OCD. Finally, speculate developmental neurobiology behaviors, particular attention including behavioral emotional regulation, suggest similarities differences making comparisons, hope open a dialogue researchers who study underlying brain pathologies associated those explore bases development.