Neuroprotective effects of acetyl-l-carnitine on lipopolysaccharide-induced neuroinflammation in mice: Involvement of brain-derived neurotrophic factor
作者： Filiz Kazak , Gul Fatma Yarim
DOI: 10.1016/J.NEULET.2017.07.059
关键词:
摘要: Neuroinflammation is the inflammation of nervous tissue that can lead to neurodegeneration. Brain-derived neurotrophic factor (BDNF) a neurotrophin which affects growth, function and survival neurons, enhances stabilization synapses, regulates synaptic branching dendrites axons. believed be involved in pathophysiology central system (CNS) diseases associated with neuroinflamation. The aim this study was investigate new protective therapeutic effect acetyl-l-carnitine (ALCAR) neuroinflammation. Acetyl-l-carnitine administered into Swiss Albino mice as 100mg/kg/day 300mg/kg/day for 5days. induced by lipopolysaccharide (LPS). Histopathological findings ALCAR administration on neuroinflammation brain were determined. Moreover, effects BDNF concentration evaluated. LPS showed higher microglial activation LPS, 100A+LPS 300A+LPS groups compared control (p 0.05). suggest dose at i.p. may have beneficial LPS-induced mice. As conclusion, used an optional neuroprotective agent attenuate inflammatory damage CNS regarding BDNF, dependent manner.
sci-hub.se 参考文章(48)
Peter S Whitton, Neuroinflammation and the prospects for anti-inflammatory treatment of Parkinson's disease. Current opinion in investigational drugs. ,vol. 11, pp. 788- 794 ,(2010)
Clive R Bramham, Sjoukje D Kuipers, Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapy. Current Opinion in Drug Discovery & Development. ,vol. 9, pp. 580- 586 ,(2006)
Sonu Singh, Akanksha Mishra, Shubha Shukla, ALCAR Exerts Neuroprotective and Pro-Neurogenic Effects by Inhibition of Glial Activation and Oxidative Stress via Activation of the Wnt/β-Catenin Signaling in Parkinsonian Rats Molecular Neurobiology. ,vol. 53, pp. 4286- 4301 ,(2016) , 10.1007/S12035-015-9361-5
Penghui Wei, Qingshen Liu, Dong Li, Qiang Zheng, Jinfeng Zhou, Jianjun Li, Acute nicotine treatment attenuates lipopolysaccharide-induced cognitive dysfunction by increasing BDNF expression and inhibiting neuroinflammation in the rat hippocampus. Neuroscience Letters. ,vol. 604, pp. 161- 166 ,(2015) , 10.1016/J.NEULET.2015.08.008
Andrea Crotti, Christopher K. Glass, The choreography of neuroinflammation in Huntington's disease Trends in Immunology. ,vol. 36, pp. 364- 373 ,(2015) , 10.1016/J.IT.2015.04.007
Y.A. Barde, D. Edgar, H. Thoenen, Purification of a new neurotrophic factor from mammalian brain. The EMBO Journal. ,vol. 1, pp. 549- 553 ,(1982) , 10.1002/J.1460-2075.1982.TB01207.X
Zhen-yu Zhang, Zhong-kai Fan, Yang Cao, Zhi-qiang Jia, Gang Li, Xiao-dong Zhi, De-shui Yu, Gang Lv, None, Acetyl-l-carnitineamelioratesmitochondrial damage and apoptosis following spinal cord injury in rats Neuroscience Letters. ,vol. 604, pp. 18- 23 ,(2015) , 10.1016/J.NEULET.2015.06.021
Yoshinori Imai, Iwao Ibata, Daisuke Ito, Keiko Ohsawa, Shinichi Kohsaka, A Novel Geneiba1in the Major Histocompatibility Complex Class III Region Encoding an EF Hand Protein Expressed in a Monocytic Lineage Biochemical and Biophysical Research Communications. ,vol. 224, pp. 855- 862 ,(1996) , 10.1006/BBRC.1996.1112
Laura R. Schaevitz, Raffaella Nicolai, Carla M. Lopez, Stefania D'Iddio, Emerenziana Iannoni, Joanne E. Berger-Sweeney, Acetyl-L-Carnitine Improves Behavior and Dendritic Morphology in a Mouse Model of Rett Syndrome PLoS ONE. ,vol. 7, pp. e51586- ,(2012) , 10.1371/JOURNAL.PONE.0051586
Weihong Lu, Chen Zhang, Zhenghui Yi, Zezhi Li, Zhiguo Wu, Yiru Fang, Association Between BDNF Val66Met Polymorphism and Cognitive Performance in Antipsychotic-Naïve Patients with Schizophrenia Journal of Molecular Neuroscience. ,vol. 47, pp. 505- 510 ,(2012) , 10.1007/S12031-012-9750-4