1,25-Dihydroxyvitamin D and the Vitamin D Receptor Gene Polymorphism Apa1 Influence Bone Mineral Density in Primary Hyperparathyroidism

摘要: Objective Parathyroid hormone (PTH) and vitamin D are the most important hormones regulating calcium metabolism. In primary hyperparathyroidism (PHPT) excessive amounts of PTH produced. Bone turnover is enhanced, leading to reduced bone mineral density elevated levels serum calcium. The aim this study was investigate relations between 25-hydroxyvitamin (25(OH)D), 1,25-dihydroxyvitamin (1,25(OH)2D) density, as well known genetic polymorphisms in receptor enzymes metabolising patients with PHPT. Design/Subjects We conducted a cross-sectional 52 PHPT. Results Mean level 25(OH)D 58.2 nmol/L median 1,25(OH)2D 157 pmol/L. Among our PHPT 36.5% had below 50 nmol/L. Serum inversely correlated distal radius (p = 0.002), but not at lumbar spine or femoral neck. polymorphism Apa1 (rs7975232) associated spine. Conclusions The results suggest that high blood concentrations may have deleterious skeletal effects. Randomized, prospective studies necessary elucidate whether supplementation additionally increases possibly enhances adverse effects on skeleton PHPT.