Serum Levels of 20 Kilodalton Human Growth Hormone (20K-hGH) in Patients with Acromegaly before and after Treatment with Octreotide and Transsphenoidal Surgery
作者： Yoshio MURAKAMI , Tadashi SHIMIZU , Masahiro YAMAMOTO , Yuzuru KATO
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摘要: Circulating human GH (hGH) consists of several molecular isoforms. It was previously reported that the proportion 20 kilodalton hGH (20K-hGH) elevated in serum patients with active acromegaly. In this study, we investigated effects octreotide and transsphenoidal adenomectomy on 20K-hGH 7 acromegalic patients. To achieve an acute effect, (100 microg) subcutaneously injected as a bolus. observe chronic therapy surgery, samples were obtained by repetitive blood sampling before 3 to 8 weeks after treatment. Serum levels 22 (22K-hGH) determined specific enzyme-linked immunosorbent assay. A bolus injection elicited parallel decrease 22K-hGH 20K-hGH, resulting unchanged total circulating hGH. The decreased 4 surgery 2 treatment for weeks. positively related mean well levels, but not IGF-I levels. These findings suggest high or per se might elicit change clearance kinetics increase
sci-hub.se 参考文章(16)
Frances M. DeNoto, David D. Moore, Howard M. Goodman, Human growth hormone DNA sequence and mRNA structure: possible alternative splicing Nucleic Acids Research. ,vol. 9, pp. 3719- 3730 ,(1981) , 10.1093/NAR/9.15.3719
Yoshihide Hashimoto, Takeshi Kamioka, Masaharu Hosaka, Kazunori Mabuchi, Akira Mizuchi, Yukio Shimazaki, Michio Tsunoo, Toshiaki Tanaka, Exogenous 20K Growth Hormone (GH) Suppresses Endogenous 22K GH Secretion in Normal Men The Journal of Clinical Endocrinology and Metabolism. ,vol. 85, pp. 601- 606 ,(2000) , 10.1210/JCEM.85.2.6377
Cesar L. Boguszewski, Gudmundur Johannsson, Bengt-Åke Bengtsson, Anders Johansson, Björn Carlsson, Lena M. S. Carlsson, Circulating non-22-kilodalton growth hormone isoforms in acromegalic men before and after transsphenoidal surgery The Journal of Clinical Endocrinology and Metabolism. ,vol. 82, pp. 1516- 1521 ,(1997) , 10.1210/JCEM.82.5.3911
Sylvain Dor�, Guy R. Brisson, Alain Fournier, Richard Montpetit, H�l�ne Perrault, Dominique Boisvert, Contribution of hGH20K variant to blood hGH response in sauna and exercise. European Journal of Applied Physiology. ,vol. 62, pp. 130- 134 ,(1991) , 10.1007/BF00626768
Mitsufumi Wada, Hiroshi Uchida, Miwa Ikeda, Bunkichi Tsunekawa, Naokazu Naito, Shinichi Banba, Eishi Tanaka, Yoshihide Hashimoto, Masaru Honjo, The 20-Kilodalton (kDa) Human Growth Hormone (hGH) Differs from the 22-kDa hGH in the Complex Formation with Cell Surface hGH Receptor and hGH-Binding Protein Circulating in Human Plasma Molecular Endocrinology. ,vol. 12, pp. 146- 156 ,(1997) , 10.1210/MEND.12.1.0054
GERHARD BAUMANN, MARK W. STOLAR, KLAUS AMBURN, Molecular forms of circulating growth hormone during spontaneous secretory episodes and in the basal state The Journal of Clinical Endocrinology and Metabolism. ,vol. 60, pp. 1216- 1220 ,(1985) , 10.1210/JCEM-60-6-1216
GERHARD BAUMANN, Growth hormone heterogeneity: genes, isohormones, variants, and binding proteins. Endocrine Reviews. ,vol. 12, pp. 424- 449 ,(1991) , 10.1210/EDRV-12-4-424
Mayumi Ishikawa, Susumu Yokoya, Katsuhiko Tachibana, Yukihiro Hasegawa, Toshiaki Yasuda, Etsurou Tokuhiro, Yoshihide Hashimoto, Toshiaki Tanaka, Serum Levels of 20-Kilodalton Human Growth Hormone (GH) Are Parallel Those of 22-Kilodalton Human GH in Normal and Short Children The Journal of Clinical Endocrinology and Metabolism. ,vol. 84, pp. 98- 104 ,(1999) , 10.1210/JCEM.84.1.5402
U.J. Lewis, L.F. Bonewald, L.J. Lewis, The 20,000-dalton variant of human growth hormone: location of the amino acid deletions. Biochemical and Biophysical Research Communications. ,vol. 92, pp. 511- 516 ,(1980) , 10.1016/0006-291X(80)90363-0
Gerhard Baumann, John G. Maccart, Klaus Amburn, The Molecular Nature of Circulating Growth Hormone in Normal and Acromegalic Man: Evidence for a Principal and Minor Monomeric Forms* The Journal of Clinical Endocrinology and Metabolism. ,vol. 56, pp. 946- 952 ,(1983) , 10.1210/JCEM-56-5-946