作者: Mayumi Ishikawa , Susumu Yokoya , Katsuhiko Tachibana , Yukihiro Hasegawa , Toshiaki Yasuda
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摘要: Twenty-kilodalton human GH (20K), which is one of the (hGH) variants, thought to be produced by alternative premessenger ribonucleic acid splicing. However, its physiological role still unclear due lack a specific assay. We have measured serum 20K and 22-kDa hGH (22K) ELISAs investigate in children. The subjects were 162 normal children, aged 1 month 20 yr; 12 patients with deficiency (GHD), 11 months 13 57 children non-GHD short stature, 2-17 girls Turner's syndrome, 5 15 yr. Samples collected at random from after provocative tests 3-h nocturnal sleep GHD, syndrome mean basal concentrations 22K 2.4 +/- 2.8 ng/mL 152.3 184.0 pg/mL boys 2.5 3.1 130.6 171.5 girls, respectively. percentages (%20K) 5.8 2.1% 6.0 3.2% 83 79 There was no significant difference %20K either among ages or between prepubertal stage pubertal girls. values samples 6.5 2.4%, 3.8%, 5.9 3.2%, these growth disorders, there throughout disorders. also correlation percentage height SD score body mass index In conclusion, constant, regardless age, sex, puberty, score, index, secretion status. regulation levels remains established.