The striate sign: peritumoural perfusion pattern of infiltrative primary and recurrent gliomas

摘要: MR perfusion depicts angiogenesis as a key factor for growth and malignancy in gliomas by means of increased regional cerebral blood volume (rCBV). The rCBV increase is not limited to the tumour area, but may also produce stripe-like pattern peritumoural that we defined “striate sign”. We evaluated if prior radiochemotherapy influences values adjacent malignant comparing treated recurrent with untreated gliomas. Ninety-three patients primary or WHO grades II–IV glial tumours underwent T2*-weighted dynamic susceptibility-weighted contrast-enhanced (DSC)-MRI. Differences normalised rCBVmax were using Kruskal−Wallis analysis post hoc tests. number cases showing hot spot (rCBVmax) and/or striate (striate sign) was assessed Fisher’s exact test. Significance level determined p < 0.05. Normalised rCBV, sign significantly lower (rCBV = 3.24 ± 1.22, 5.05 2.27 10/24) compared grade IV 4.44 1.39, 7.31 3.0 17/21, respectively). There fewer III than transformed II tumours. degree around differ between previously These differences might be due post-therapeutic changes tumour-associated microvasculature radiochemotherapy. Spectroscopic imaging provide further insights into biology.