Angiogenesis in brain tumors: pathobiological and clinical aspects

摘要: Angiogenesis is the outgrowth of new blood vessels from preexistent vasculature. In 1971, Folkman hypothesized that solid tumors are dependent on angiogenesis for sustained growth and anti-angiogenic treatment a potential antineoplastic therapy. Because glioblastoma multiforma (GBM) frequently shows florid microvascular proliferation (MVP), this tumor has been considered since then as suitable candidate such attempts to eradicate or control neoplasm by interfering with its supply. Indeed, in animal models glioma xenografts can be inhibited targeting angiogenic process. However, unlike many xenografts, human infiltrating gliomas GBMs have diffuse infiltrative pattern, may suffice provide cells much their supply, particularly critical peripheral margins. Thus, while attractive concept, therapy GBM must address anatomic vascular realities neoplasm. Even if ultimately role neoplasms, there host other intracranial neoplasms whose discrete architecture might make them candidates This review summarizes process suggests types which efficacy studied.