Structures of Rotavirus Reassortants Demonstrate Correlation of Altered Conformation of the VP4 Spike and Expression of Unexpected VP4-Associated Phenotypes
作者： Joseph B. Pesavento , Angela M. Billingsley , Ed J. Roberts , Robert F. Ramig , B. V. Venkataram Prasad
DOI: 10.1128/JVI.77.5.3291-3296.2003
关键词:
摘要: Numerous prior studies have indicated that viable rotavirus reassortants containing structural proteins of heterologous parental origin may express unexpected phenotypes, such as changes in infectivity and immunogenicity. To provide a basis for alterations phenotypic expression, three-dimensional analysis these was conducted. The structures the show while VP4 generally maintains structure when moved to protein background, certain reassortants, there are subtle conformation VP4. correlated with expression VP4-associated phenotypes. Interactions between VP7 expressing phenotypes appeared induce conformational seen
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