Reproductive Factors, Heterogeneity, and Breast Tumor Subtypes in Women of Mexican Descent

摘要: Background: Published data support the presence of etiologic heterogeneity by breast tumor subtype, but few studies have assessed this in Hispanic populations. Methods: We subtype prevalence and associations between reproductive factors subtypes 1041 women Mexican descent enrolled a case-only, binational cancer study. Multinomial logistic regression comparing human epidermal growth factor receptor 2 positive (HER2+) tumors triple negative (TNBC) to luminal A was conducted. Results: Compared with tumors, those later age at first pregnancy were less likely TNBC (odds ratio [OR], 0.61; 95% CI, 0.39-0.95), whereas ≥ 3 full-term pregnancies more (OR, 1.68; 1.10-2.55). lower odds shown for longer menstruation duration, whether prior 0.78; 0.65-0.93 per 10 years) or menopause 0.79; 0.69-0.91 years). Patients who reported breastfeeding >12 months over twice as than 2.14; 1.24-3.68). Associations HER2+ weak non-existent except interval last diagnosis. Conclusions: Findings show population unique profiles. Impact: Identification etiologically distinct can further improve our understanding disease help provide personalized prevention treatment regimens.