Mouse duplicate genes are as essential as singletons.
作者： Ben-Yang Liao , Jianzhi Zhang
DOI: 10.1016/J.TIG.2007.05.006
关键词:
摘要: Duplicate genes in mouse are widely thought to have functional redundancy, and be less essential than singleton genes. We analyzed nearly 3900 individually knocked out discovered that the proportion of is ∼55% both singletons duplicates. This suggests mammalian duplicates rarely compensate for each other, absence phenotypes mice deficient a duplicate gene should not automatically attributed paralogous compensation.
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