The complex relationship of gene duplication and essentiality
作者： Takashi Makino , Karsten Hokamp , Aoife McLysaght
DOI: 10.1016/J.TIG.2009.03.001
关键词: Multicellular organism 、 Gene 、 Genetics 、 Minimal genome 、 Drosophila melanogaster 、 Function (biology) 、 Gene duplication 、 Genome 、 Drosophilidae 、 Biology
摘要: In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than singleton gene. By contrast, previous analyses showed mouse were as essential singletons. We show relationship between gene duplication essentiality complex multicellular organisms, with developmental duplicated by whole being more other genes.
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