HERG K+ Channel, a Regulator of Tumor Cell Apoptosis and Proliferation
作者： Stanley Nattel , Jingxiong Wang , Huizhen Wang , Baofeng Yang , Yiqiang Zhang
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摘要: The human ether-a-go-go related gene (HERG) encodes K+ channel identifiedas a molecular target for mutations underlying some forms of thelong QT syndrome, a lethal cardiac arrhythmia. Recent studies revealed that HERG is abundantly expressed in a variety of tumor cells. Yet, the role of HERG in tumor cells had remained unclear. Here, we show that HERG conductance markedly promotes H2O2-induced apoptosis of various tumor cells, whereas HERG expression facilitates the tumor cell proliferation caused by tumor necrosis …
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