Altered microRNA expression profile in amyotrophic lateral sclerosis: a role in the regulation of NFL mRNA levels
作者： Danae Campos-Melo , Cristian A Droppelmann , Zhongping He , Kathryn Volkening , Michael J Strong
关键词:
摘要: Background Amyotrophic Lateral Sclerosis (ALS) is a progressive, adult onset, fatal neurodegenerative disease of motor neurons. There emerging evidence that alterations in RNA metabolism may be critical the pathogenesis ALS. MicroRNAs (miRNAs) are small non-coding RNAs key determinants mRNA stability. Considering miRNAs increasingly being recognized as having role variety diseases, we decided to characterize miRNA expression profile spinal cord (SC) tissue sporadic ALS (sALS) and controls. Furthermore, performed functional analysis identify group dysregulated could responsible for selective suppression low molecular weight neurofilament (NFL) observed
biomedcentral.com
springer.com
core.ac.uk
paperity.org参考文章(51)
J. Sreedharan, I. P. Blair, V. B. Tripathi, X. Hu, C. Vance, B. Rogelj, S. Ackerley, J. C. Durnall, K. L. Williams, E. Buratti, F. Baralle, J. de Belleroche, J. D. Mitchell, P. N. Leigh, A. Al-Chalabi, C. C. Miller, G. Nicholson, C. E. Shaw, TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis Science. ,vol. 319, pp. 1668- 1672 ,(2008) , 10.1126/SCIENCE.1154584
Michael J. Strong, Kathryn Volkening, Robert Hammond, Wencheng Yang, Wendy Strong, Cheryl Leystra-Lantz, Christen Shoesmith, TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein Molecular and Cellular Neuroscience. ,vol. 35, pp. 320- 327 ,(2007) , 10.1016/J.MCN.2007.03.007
Wei-Wen Ge, Cheryl Leystra-Lantz, Weiyan Wen, Michael J. Strong, Selective Loss of trans-Acting Instability Determinants of Neurofilament mRNA in Amyotrophic Lateral Sclerosis Spinal Cord Journal of Biological Chemistry. ,vol. 278, pp. 26558- 26563 ,(2003) , 10.1074/JBC.M302886200
Soon-Tae Lee, Kon Chu, Woo-Seok Im, Hye-Jin Yoon, Ji-Yeon Im, Jung-Eun Park, Ki-Ho Park, Keun-Hwa Jung, Sang Kun Lee, Manho Kim, Jae-Kyu Roh, Altered microRNA regulation in Huntington's disease models Experimental Neurology. ,vol. 227, pp. 172- 179 ,(2011) , 10.1016/J.EXPNEUROL.2010.10.012
Paola Tognini, Elena Putignano, Alessandro Coatti, Tommaso Pizzorusso, Experience-dependent expression of miR-132 regulates ocular dominance plasticity Nature Neuroscience. ,vol. 14, pp. 1237- 1239 ,(2011) , 10.1038/NN.2920
Henriett Butz, István Likó, Sándor Czirják, Péter Igaz, Márta Korbonits, Károly Rácz, Attila Patócs, MicroRNA profile indicates downregulation of the TGFβ pathway in sporadic non-functioning pituitary adenomas Pituitary. ,vol. 14, pp. 112- 124 ,(2011) , 10.1007/S11102-010-0268-X
Wei-Wen Ge, Weiyan Wen, Wendy Strong, Cheryl Leystra-Lantz, Michael J. Strong, Mutant Copper-Zinc Superoxide Dismutase Binds to and Destabilizes Human Low Molecular Weight Neurofilament mRNA Journal of Biological Chemistry. ,vol. 280, pp. 118- 124 ,(2005) , 10.1074/JBC.M405065200
Daehyun Baek, Judit Villén, Chanseok Shin, Fernando D. Camargo, Steven P. Gygi, David P. Bartel, The impact of microRNAs on protein output Nature. ,vol. 455, pp. 64- 71 ,(2008) , 10.1038/NATURE07242
Julius Brennecke, Alexander Stark, Robert B Russell, Stephen M Cohen, None, Principles of MicroRNA–Target Recognition PLOS Biology. ,vol. 3, ,(2005) , 10.1371/JOURNAL.PBIO.0030085
Kathryn Volkening, Cheryl Leystra-Lantz, Wenchang Yang, Howard Jaffee, Michael J. Strong, Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS). Brain Research. ,vol. 1305, pp. 168- 182 ,(2009) , 10.1016/J.BRAINRES.2009.09.105